EstimatingtheGenderDistributionofPatientswithWild-TypeTransthyretinAmyloidCardiomyopathy:ASystematicReviewandMeta-AnalysisCardiolTherReviewEarlyRecent,Dec14,./s--05-3本文由“天纳”临床学术信息人工智能系统自动翻译点击文末“阅读原文”下载本文PDFIntroductionThisstudyinvestigatesthegenderdistributioninpatientsdiagnosedwithwild-typetransthyretinamyloidosiscardiomyopathy(ATTRwt).本研究探讨野生型转甲状腺素淀粉样变性心肌病（ATTRwt）患者的性别分布。MethodsAsystematicreviewandmeta-analysisofthemaleproportionindiagnosedATTRwtpatientswereconducted.Toavoidoverlappingpopulation,pooledestimatesintheprimaryanalysiswerebasedonalluniquestudies.Insecondaryanalyses,weconsideredpredefinedsubsetsofstudiesbasedonstudysamplesize,recruitmentyears,geography,studydesign,ageatdiagnosis,andmethodofdiagnosis.Additionalmeta-regressionanalysesweretestedforpotentialdeterminantsofgenderdistribution.对确诊的ATTRwt患者的男性比例进行了系统回顾和meta分析。为了避免人口重叠，初步分析中的合并估计是基于所有独特的研究。在二次分析中，我们考虑了基于研究样本量、招募年份、地理位置、研究设计、诊断年龄和诊断方法的预定义研究子集。对性别分布的潜在决定因素进行了额外的元回归分析。ResultsTwenty-eightuniquestudies(patients)wereincludedinthemeta-analysis.MaleproportioninpatientswithATTRwtwas86.9%(95%confidenceinterval81.5–91.6%).Studies,includingpatientsolderthan80?yearsatdiagnosis,hada29.1%(pvalue??0.)lowermaleproportion
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