英文原文:
IschemicHeartDisease
Ischemicheartdiseaseisawell-establishedriskfactorforAF.MechanismsforthedevelopmentofAFinischemicheartdiseasemayinclude:(1)directatrialischemiaresultinginfibrosisandincreasedrefractoryperiodheterogeneityand(2)inflammationoriginatingfromatheroscleroticcoronaryarteriesandexpandingtotheatrialtissue.
翻译
缺血性心肌病
缺血性心肌病是房颤的确定风险因子。缺血性心肌病导致房颤的机制包括:(1)心房缺血导致心房纤维化,增加心房不应期异质性;(2)冠状动脉粥样硬化产生的炎症扩散至心房组织。
英文原文:
Myocardialischemiaresultsinmyocardialstiffness,elevatedleftventricularfillingpressures,increasedatrialstretch,andalteredhemodynamics,generatingasuitablesubstratefordevelopmentofAF.Inasmallstudy(n=90),P-wavedurationincreasedafteranteriorwallmyocardialinfarction(MI),andthisincreasewasindependentlyassociatedwiththeseverityofleftventriculardiastolicdysfunction.
翻译
心肌缺血导致心肌僵硬、左室充盈压升高、心房张力增加、血流动力学改变,产生房颤发生的基质。小规模研究(90例患者)显示,前壁心梗后P波时限增加,而P波时限的增加与左室舒张功能严重受损独立相关。
英文原文:
P-wavedurationwassignificantlyhigherinpatientsthatdevelopAFinasmallstudyofacuteanteriorwallMIcases.However,inthesamestudyP-wavedurationwasnotindependentlyassociatedwithAFaftermultivariableadjustments.P-waveareaandP-waveterminalforcehavenotbeenstudiedincoronaryarterydisease.StudiesexaminingabnormalPWIsinthesettingofcoronaryarterydiseasehavenotbeenconductedtoourknowledge.Administrationofintravenousβ-blockersorrevascularizationwithangioplastyduringacutemyocardialinfarction(AMI)hasbeenshowntodecreaseP-waveduration.ThesignificanceofthisdecreaseofP-wavedurationintheshort-andlong-termprognosisandriskofAFremaintobeexplored.
翻译
例急性前壁心梗患者的研究显示发生房颤患者的P波时限显著增加。然而,这些小规模研究显示校正多因素后P波时限与房颤独立相关。尚无冠心病患者P波下面积和P波终末电势方面的研究。据我们所知,尚无有关冠心病患者异常PWIs的研究。急性心肌梗死患者静脉应用β受体阻滞剂或再血管化治疗可以缩短P波时限。尚需进一步探索P波时限缩短对房颤风险的短期和长期预后意义。(翻译:首都医科医院郑志涛)
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